Monthly Archives: March 2018

Doctors of Royapettah Hospital bring out a book on toxicology

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Doctors of the Department of Internal Medicine at Government Royapettah Hospital have brought out a book, Manual of Toxicology — An Indian Perspective, which, they say, will fill a lacunae in the knowledge about poisons.

“Most toxicology manuals are silent on many of the Indian posions, as they have been written from a western perspective. This book is based on our experience treating cases involving toxins,” says Dr. A. Shaik Sulaiman Meeran, one of the doctors who spearheaded this book project.

Dr. P. Paranthaman was the editor-in-chief. Dr. Sulaiman, Dr. A. Samuel Dinesh and Dr. D. Venkateswaralu served as associate editors and Dr. P. Raja as co-editor. The book has been brought out by Chess Educational Publishers.

Dr. Sulaiman says that knowing the sources of danger will prevent accidental ingesting of poisons or strikes by venomous reptiles and insects.

Knowing where to seek help will be a crucial factor in recovery.

He says snake bite cases from the southern suburbs, which include Tambaram and surrounding areas, parts of Old Mahabalipuram Road and East Coast Road are common. Anti-venom serum for treatment of bites by cobra, viper and krait is available. Government general hospitals have them.

Residents of semi-urban areas can face the problem of snake bikes, it is available in primary health centres, he says. Here is a word of caution. “Ninety percent of the sea snakes are poisonous and there is no anti-venom serum for them. Only supportive treatment can be given. Sea snakes are sometimes found near fishermen’s settlements. They get entangled in fishermen’s nets and are brought ashore. There is always a high possibility of finding them near fishermen’s hamlets on East Coast Road,” says Dr. Sulaiman.

source: http://www.thehindu.com / The Hindu / Home> News> Cities> Chennai / March 23rd, 2018

Saluting women trailblazers

WomenAwards24mar2018

The Hindu ‘World of Women 2018’ awards presented

The Hindu ‘World of Women 2018’ awards that were given away on Friday celebrated talent, excellence and the accomplishments of women across various fields. The awardees were recognised not only for their contribution to their respective fields but also to society at large.

Nirmala Lakshman, director, The Hindu Group, welcomed the audience and the chief guest Kiran Bedi, Lieutenant Governor of Puducherry, gave away the awards to 11 achievers.

Mrs. Y.G. Parthasarathy, founder and dean, P. S. B. B. Group of Institutions, was awarded The Hindu Torchbearer award — recognising excellence in education. The 92-year-old came to receive the award with her grand daughter-in-law, who spoke on her behalf. “I began my career as a journalist with The Hindu. I was the first woman journalist back then and I remember interviewing the cosmonaut Yuri Gagarin. I still have miles to go in keeping up with technological developments. I accept this award with all humility,” she read.

R. Tara, director, SCARF, received the Excellence in Healthcare award. She recalled the story of a young girl, Shanti, from a village in Tamil Nadu, who topped her school but developed schizophrenia. Since her brother didn’t know how to handle her, she was chained near a cowshed for over a year. “Today, she can take up a part-time job,” she said.

Beno Zephine N.L., the first visually-challenged IFS officer, was awarded the Inspiration award, in absentia. The Entrepreneur award was given to Nina Reddy, joint managing director, Savera Hotel; Visalakshi Ramaswamy, founder of M.Rm.Rm. Cultural Foundation, received The Hindu Agriculture and Rural Development Award. Akhila Srinivasan, MD, Shriram Life Insurance, was presented The Hindu Business Woman Award. The team from Tamil Nadu, which won the 23rd National Women’s Football Championship, was awarded The Hindu Flying Colours Award for Excellence in Sports.

Supriya Sahu, IAS, Director General of Doordarshan, received the Contribution to Society award. “My journey as an IAS officer from U.P. and Bihar to Kanniyakumari and The Nilgiris district has taught me how much I can serve as a government officer,” she said. Dancer Malavika Sarukkai, who received The Hindu Heritage in Arts and Entertainment Award, spoke of the need to look at dance beyond the ‘performative’. Actor Nayanthara won the Dazzler award.

Lifetime of service

The Hindu Lifetime Achievement Award was given to V. Shanta, founder/chairperson, Cancer Institute, Adyar. “I dedicate this award to the memory of Dr. Muthulakshmi Reddy. It is 62 years today and I continue with this institution. We have been unique because we continue the same ethos even when health, which was a human service, has now become an industry,” she said.

“Each one of us women has fought our own battles to reach the centrestage; we must continue to be a support system for each other,” said Ms. Bedi.

source: http://www.thehindu.com / The Hindu / Home> News> Cities> Chennai / by Staff Reporter / Chennai – March 24th, 2018

Tirupur athlete lands in Australia to take part in Commonwealth Games

Dharun Ayyasamy   | Photo Credit: HANDOUT
Dharun Ayyasamy | Photo Credit: HANDOUT

Dharun Ayyasamy (21), an Olympian athlete from Tirupur who recently qualified for Commonwealth Games, has reached Gold Coast in Australia in advance to get acclimatised to the conditions at the Games venue.

“Training at the host country in advance will enhance the chances of a medal,” said J. Alagesan, the athlete’s personal coach.

Dharun qualified for the Commonwealth Games by finishing with a national record performance of 49.45 seconds in the men’s 400 m hurdles at the Federation Cup event at Patiala on March 8.

“What makes the selection fascinating is that the timing was exactly the one set worldwide for selection to the Commonwealth Games this time. The performance at Patiala thus broke the 10-year-old national record held by Joseph Ganapathiplackal Abraham of Kerala in 2007”, Mr. Alagesan said.

Dharun, who represented India in the Rio Olympics in 2016 in 4X 400 metres relay, had started his preparations for the Commonwealth Games immediately after the Patiala event.

“I practised at Sports Authority of India’s training facility at Patiala before embarking on the Australian trip”, Dharun told The Hindu over phone.

source: http://www.thehindu.com / The Hindu / Home> News> Cities> Coimbatore / by R. Vimal Kumar / Tirupur – March 22nd, 2018

Dravidian language family is 4,500 years old: study

The Dravidian language family’s four largest languages — Kannada, Malayalam, Tamil and Telugu — have literary traditions spanning centuries, of which Tamil reaches back the furthest, researchers said.

DravidianFamilyCF21mar2018

The Dravidian language family, consisting of 80 varieties spoken by nearly 220 million people across southern and central India, originated about 4,500 years ago, a study has found.

This estimate is based on new linguistic analyses by an international team, including researchers from the Max Planck Institute for the Science of Human History in Germany, and the Wildlife Institute of India in Dehradun.

The researchers used data collected first-hand from native speakers representing all previously reported Dravidian subgroups. The findings, published in the journal Royal Society Open Science, match with earlier linguistic and archaeological studies.

South Asia, reaching from Afghanistan in the west and Bangladesh in the east, is home to at least six hundred languages belonging to six large language families, including Dravidian, Indo-European and Sino-Tibetan.

The Dravidian language family, consisting of about 80 language varieties (both languages and dialects) is today spoken by about 220 million people, mostly in southern and central India, and surrounding countries.

The Dravidian language family’s four largest languages — Kannada, MalayalamTamil and Telugu — have literary traditions spanning centuries, of which Tamil reaches back the furthest, researchers said.

Along with Sanskrit, Tamil is one of the world’s classical languages, but unlike Sanskrit, there is continuity between its classical and modern forms documented in inscriptions, poems, and secular and religious texts and songs, they said.

“The study of the Dravidian languages is crucial for understanding prehistory in Eurasia, as they played a significant role in influencing other language groups,” said Annemarie Verkerk of the Max Planck Institute for the Science of Human History.

Neither the geographical origin of the Dravidian language nor its exact dispersal through time is known with certainty.

The consensus of the research community is that the Dravidians are natives of the Indian subcontinent and were present prior to the arrival of the Indo-Aryans (Indo-European speakers) in India around 3,500 years ago.

Researchers said that it is likely that the Dravidian languages were much more widespread to the west in the past than they are today.

In order to examine questions about when and where the Dravidian languages developed, they made a detailed investigation of the historical relationships of 20 Dravidian varieties.

Study author Vishnupriya Kolipakam of the Wildlife Institute of India collected contemporary first-hand data from native speakers of a diverse sample of Dravidian languages, representing all the previously reported subgroups of Dravidian.

The researchers used advanced statistical methods to infer the age and sub-grouping of the Dravidian language family at about 4,000-4,500 years old.

This estimate, while in line with suggestions from previous linguistic studies, is a more robust result because it was found consistently in the majority of the different statistical models of evolution tested in this study.

This age also matches well with inferences from archaeologywhich have previously placed the diversification of Dravidian into North, Central, and South branches at exactly this age, coinciding with the beginnings of cultural developments evident in the archaeological record.

source: http://www.thehindu.com / The Hindu / Home> Science / by PTI / Berlin – March 21st, 2018

Now, Sing Thyagaraja Kritis in Malayalam

Retired principal translates 101 compositions of the saint-poet

The Telugu compositions of Sri Thyagaraja have reached God’s Own Country and are available to music connoisseurs in “His own language”.

This was made possible by the efforts of Latha Varma, retired Principal of Madurai-based Sri Sadguru Sangeetha Vidyalayam College of Music and Research Centre. Quite surprisingly, Tamil acted as the bridge in translating the Telugu compositions into Malayalam.

Ms. Varma, who belongs to the royal family of Ernakulam, joined the famed college in Madurai when she was 24 and retired a couple of years ago. As Malayalam is her mother tongue and she gained proficiency in Tamil with her prolonged stay in Madurai, she decided to go the extra mile to learn Telugu literature too. And she did master it with élan through a certificate and diploma course from Madurai Kamaraj University.

Though Thyagaraja kritis are sung world over by people of all languages, many are do not know Telugu and as such miss out on its literary beauty. The mellifluous note and rhythm come in for appreciation, but the ‘Bhava’ (substance) more often than not gets lost. It is this void that the musicologist wanted to fill, at least in Malayalam.

She hand-picked 101 most popular compositions of the saint-poet and gave a word-by-word translation (Prathipadartham) and also a gist (Thathparyam) of each verse. As senior Telugu professor T.S. Giriprakash Rao translated the Telugu verses into Tamil, she picked them up for translation into Malayalam.

An academician, performer cum researcher, Ms. Varma spoke to The Hindu on the sidelines of a seminar on “Group kritis of different vaggeyakaras,”organised by Sri Padmavathi Mahila Viswa Vidyalayam’s (SPMVV) Department of Music and Fine Arts, where she was the key-note speaker.

The translation work, which she calls her “pet project”, lasted for two years. “The copies are now available at the Maharaja’s College for Women and Kerala University, both in Thiruvananthapuram, and the Chittur College in Palakkad. I will soon present some [copies] to the Maharaja’s College in Ernakulam,” Ms. Varma said.

Ms. Varma was felicitated by SPMVV Rector V. Uma, Dean (Social sciences) D.B. Krishnakumari, seminar coordinator K. Saraswathi Vasudev and academic Dwaram Lakshmi on the occasion.

source: http://www.thehindu.com / The Hindu / Home> News> States> Andhra Pradesh / by A.D. Rangarajan / Tirupati – March 21st, 2018

LR Eswari, the finest example of an unschooled genius

LREaswariCF21mar2018

LR Eswari dominated the South Indian film industry during the Sixties and Seventies. A phenomenal talent that she was, any kind of song just came to her

There’s something curiously common about several playback singers of yesteryear – most of them have had no formal training in music in their formative years. On listening to their singing, if one feels it is a phenomenon it is not an amplified statement. LR Eswari, the playback singer who was a rage in the South Indian film industry during the Sixties and Seventies, is the finest example of an unschooled genius. She was prodigious to say the least – her sophistication, versatility, effortlessness… would make one want to believe that there is something to music beyond the rigours of sadhana. Her exceptional voice range could manoeuvre complex ideas and a gamut of emotions at the speed of the mind – sensuous to spiritual, all at one go. The thought and its physical manifestation fused in Eswari’s music. In her, the song and the singer were not separate entities. Altering the very meaning of the creative process itself, in Eswari’s music, the melody began in the composer’s mind and ended in the singer’s articulation of it.

Let us take the song “Sityaako Sidkyaako” from the film, Veera Sankalpa (1962, music by Rajan-Nagendra). Operating within a folk framework, the song, in my opinion is among the most beautiful love songs. An extraordinary composition, the song has folk inflections and typical folk phrases; it is soft, breezy and melodious. What Eswari does to this song is fantastic – she doesn’t give it a monochromatic shade of love, but packs in all its shades so sensitively that you know that it is not an ordinary mind at work. A voice that has amazing throw and energy, becomes so tender in this song: there is the intensity of passionate love, an eternal promise and all this she conveys through intonations. There are two similar folk phrases in the song, “ha ha” at the end of the stanza and “oh hoi” at the end of the refrain “Sityaako Sidkyaako Nanna Jaana”. The former, she works on like a caress with a small silence, and the latter with a playful, folk abandon . With this Eswari unravels the drama of love like a seasoned actor. Next, when she sings the “Tandana tana” she heightens the energy in her voice celebrating the beauty of their feelings for each other. This one song can become a case study for the remarkable singer that she was. In fact, this folk abandon that was part of her sensibility, catapulted her into one of the finest singers of cabaret songs.

Lourde-Mary Rajeshwari, who later became LR Eswari, is a Roman Catholic from Tamil Nadu. Her mother Regina Mary Nirmala sang for chorus in films. As a child, she accompanied her mother to the studios, and soon became a chorus singer herself. But within no time, her potential was recognised and she became the main singer. As a 19-year-old, under KV Mahadevan’s direction, LR Eswari sang “Ivare Thaan Avarey”, and in no time became the favourite of all top music composers of her time.

Eswari sang plenty of songs for Kannada films, and each of them is a masterpiece, they were songs that nobody else could sing but her. “Suma Baaleye Premada Siriye” (Chandavalliya Thota, 1970) is in a way the opposite of “Sityaako Sidkyaako”. A waltz kind of song, it has a western approach (listen to the subtly jagged way in which “Bali saari begane baara” is composed). Eswari gives an authentic touch to the highs and lows in her sprightly demeanour. Each song that she has sung is distinct. “Rasika Rasika” (1970, Bhupathi Ranga) has a narrative that is entirely different from “Dooradinda Bandavare” (Taayi Karulu, 1962). “Dooradinda Bandantha”, rich and robust in its soundscape, was a typical R.D. Burman kind of song, “Bawaju Katti Nodu Baaro” (Sipayi Ramu,1972) was earthy folk, “Ayyayyo Halli Mukka” mocked the folk and had parts where it imitated the Japanese pentatonic, “Aasha Vilasi Ee roopa rashi” (Mallammana Pavada, 1969) was oozing sensuality… Eswari delivered each of these songs as is if she was native to them. Her high voltage, nasal rich voice had a sophisticated understanding which gave the songs a unique quality.

How does one explain Eshwari’s musical talent? Does one call it intuitive, a feeling-based perception? But can such feelings exist in the absence of observation of this world? So, observation and intuition are not necessarily counter to each other, and in her case, one was constantly informing the other, as also forming her music. They were not separate from each other, but supporting each other. Finally, whatever be the meaning of the song that Eswari renders, her notion of music is spiritual which is transferred to the experience of the listener.

If one considers her huge body of work across Telugu, Tamil, Kannada, Malyalam and Hindi, Eswari is perhaps among the most versatile singers India has produced. Her voice, her rendition, her range, equals the best. Yet, when we speak of versatility, why do we invariably speak only of Asha Bhosle and never of singers like Eswari? If S Janaki refused the Padmabhushan award conferred on her in 2013, she had a just case.

Inner Voice is a fortnightly column on film music

source: http://www.thehindu.com / The Hindu / Home> Entertainment> Movies / by Deepa Ganesh / March 21st, 2018

Joshna Chinappa and Velavan Senthilkumar figure in ASF Awards

JoshnaKF20mar2018

Chennai:

Leading lady of Indian squash Joshna Chinappa and a former junior star Velavan Senthilkumr figure in the Asian Squash Federation’s list of performance awards for the year 2017.

Another Indian to get noticed is Deepak Mishra, a former player who has become a coach at the Indian Squash Academy. Deepak is to be presented with the Certificate of Recognition by the ASF.

Joshna’s best moments last year came in the Asian Individual championship which was held in April here at the Express Avenue mall where she made history by becoming the first Indian to win the coveted championship honours. For her stupendous show the Asian body chose her for the Dato Alex Lee award (outstanding performance of the year – Senior). The award for the best male player in this category went to Max Lee of Hong Kong.

Velavan had the distinction of winning the British Junior Open U-19 title for the Drysdale Cup in January in what was an historic occasion for the country with three Indians taking the first three positions. Velavan won the gold, Abhay Singh the silver and Aditya Raghavan the bronze. Velavan also featured in the title-win over Malaysia in the Asian junior team championship held in Colombo in February. For his overall show of excellence, the ASF chose him for the Hassan Musa Award ( outstanding performance of the Year- junior). The award for the female player went to Satomi Watanabe of Japan.

In all there were seven categories of awards, including for Coaches. There were 12 nominations from four countries for the Performance awards and nine nominations from six countries for the Coaches awards. The awards are to be presented at the Asian Team Championships to be held this year in Cheongju in Korea.

source: http://www.timesofindia.indiatimes.com / The Times of India / News> Sports News> Others / by Damayanti Dasgupta / TNN / March 20th, 2018

‘I know I can do it’

Urmila Surana with her medal from the Mumbai Marathon | Photo Credit: The Hindu
Urmila Surana with her medal from the Mumbai Marathon | Photo Credit: The Hindu

Coimbatorean Urmila Surana on running marathons and preparing for the World Masters Athletic Meet in Spain later in the year

“I am young. At times my husband says that I am not, but I know better,” laughs 52-year- old Urmila Surana, who has participated in 25 marathons from 2015 and had a podium finish in all. “My daughters are both married and my responsibilities are over. Now is the time to explore my capabilities.”

Surana’s fitness routine is strict. “I wake up at 4.30 am, workout for an hour, finish the kitchen chores, go for swimming class, and badminton sessions. I also do yoga and have recently started cycling. I go to bed by 9.30 pm everyday. Sleeping early and taking a day off from workouts once a week is important for the body to recover.” She is also particular about her diet. “I am a vegetarian. So I eat lots of sprouts, sweet potatoes and drink orange and beetroot juice.”

Her interest in marathons began after reading an article on the Coimbatore Marathon. “I enrolled for the 10K in the veteran category. And I came first.” It took her six months to progress to 21K.

“That was also in Coimbatore and I came second.” But she doesn’t have good memories of this marathon. “I was tired and exhausted. I spoke to fellow runners and understood that I lacked strength training. So I enrolled for swimming lessons.” Playing badminton also helped her to build up her endurance.

In January, she participated in her first 42K at the Mumbai Marathon. “I could not sleep the previous night. I was worried about whether I would be able finish it. But it was smooth and I enjoyed the run. That evening I got a call saying I had got the second place for my time of four hours 30 minutes. I was surprised.”

Surana has run marathons in Chennai, Hyderabad, Bengaluru and Kochi. “The Hyderabad one was the most difficult. It was a 21K and we had to run over six steep bridges. This year I am going to enrol for the 42K with 16 bridges.”

She has been selected to represent India at World Masters Athletics Championships to be held in Spain in September. “The selection process was long. I had to clear the district, state and national level trials. I am now qualified to participate in 800m, 1500m, 5K and 10 K runs and the 5K walk.” She has been training since November last year. “My coach Vairavanathan gives me confidence. I am enrolling for the Kochi 42K marathon this year. If I win, I will get a chance to participate in the Boston marathon. I know I can do it.”

She believes that everyone should take some time out for themselves to stay fit. “One hour is all it takes.”

source: http://www.thehindu.com / The Hindu / Home> Life & Style> Fitness / by Susan Joe Philip / March 19th, 2018

What made D.K. Pattammal a trendsetter?

D.K. Pattammal performing for Kalaniketan in 1959. Photo: Special Arrangement
D.K. Pattammal performing for Kalaniketan in 1959. Photo: Special Arrangement

Thanks to DKP, women musicians stand out not only in classical but cine field too, where she set a new path

How often do we get to celebrate the centenary of a musician who still shines as a singular phenomenon in the world of classical music? Rarer if that musician left deep imprint on all spheres of art and life and went around with an innocent smile and feet well grounded! D. K. Pattammal’s centenary gives us an opportunity to revisit traditional values, ethics and unflinching classicism. Her 99th birthday concludes and 100th begins on March 19. A function to mark this has been arranged at Narada Gana Sabha, Chennai, tomorrow, March 17. Among others, the Vice-President of India and the Governor of Tamil Nadu are expected to participate.

As T. S. Parthasarathy said, “Pattammal’s greatness in the field is neither an accident nor a fortuitous coincidence. Prodigious effort, supported by a whole set of gifts bestowed on her by God and combined with a mighty stream of musical and artistic elements, have gone into the making of her art. Wonderfully assimilating and adapting, she pressed them into service to fashion her unique style. The results are an incomparable melodic richness, clarity and assurance that have few equals in the realm of Indian music even today.”

How can one ever imagine today, a Brahmin woman opting for a singing career a hundred years ago, defying the restrictions imposed by the community? Rukmini Devi Arundale had already cut the Gordian knot to become the first Brahmin woman to enter the Bharatanatyam field as a dancer. Still, it was with misgivings that Pattammal’s father agreed to her music being recorded by the gramophone company, when she was just thirteen. Then began the journey of tussles and challenge and today, thanks to her fortitude and forbearance, millions of woman singers and instrumentalists stand out not only in classical but cine field too, where she set a new path.

Music Academy invited her to sing when she was seventeen and she sang there uninterrupted for over 50 years and the last many years without receiving any as remuneration. Pattammal, was already a national icon by then, with record makers and film music producers, AIR and music organisations employing her versatility. Thanks to her husband R. Iswaran, who let go his well-paid Government job just to administer her career, Pattammal emerged as the first full-time professional woman musician of India. Not just being the first, but being on par, if not better than her male counterparts in all facets of music, especially in singing Ragam, Thanam and Pallavi.

Appeals to all

Her sonorous voice, uncanny musical acumen and complete dedication were well channelled, with the help of her gurus, in producing music that would satisfy the highbrow critic and provide joy to the lay rasika. There was no tentative attempt at perfection and every new exercise was an effort to better the best. Ananth Vaidhyanathan, noted voice specialist, once mentioned to this writer that only two musicians in this country had voice culturing woven into their music and hence sang with ease and firmness through their long career — Kishori Amonkar in the North and D. K. Pattammal in the South. Pattammal’s rendition of ‘Sri Jalandharam Ashrayayamyaham’ with breathless chittaswaras, a few months after she turned 79, can leave a musician of any generation gasping.

Pattammal was strongly attracted by the music of Ariyakkudi Ramanuja Iyengar. Ariyakkudi in turn regarded her as worthy counterpart among women.

Pattammal’s own style in many ways smacked of Ariyakkudi in its solidity and right mix of madhyama and vilamba kalam. Semmangudi Srinivasa Iyer had no hesitation in openly proclaiming that what Ariyakkudi was to male singers, Pattammal was to women. It looks like only a handful of musicians in the last century won the acceptance of their seniors, peers and juniors, very rare for a musician however intelligent or popular. Amongst them were the invincible Tiger Varadhachariar and later D.K. Pattammal.

Now, what marked her music?

— Uncompromising adherence to tradition

— Dedication to the art, with no eye on returns or glamour.

— Judicious selection of what to offer in her concerts, with dignity and spark and

— A rare sense of depth and bhavam communicated with ease and without sentimentality.

Thinking musician

Every composition she took up was studied in its structure, analysed in its scope and finally patterned into her own style as its most defined version. That is why whatever she sang still stands as a guiding light.

Think of a young Pattammal, who with the full support of her father Krishnaswamy Dikshitar, sang patriotic songs to hundreds and thousands braving the oppressive British Raj. The songs had strong words. She didn’t fear arrest. Luckily, she escaped it! She considered singing Bharatiar’s ‘Aaduvome’ over AIR at the stroke of midnight on August 15, 1947, as a cherished occasion in her life.

As many as 55 film hits from ‘Tyaga Bhoomi’ to ‘Hey Ram,’ several patriotic songs, a classical repertoire that ranged from Tamil hymns to Bhajans of composers including her contemporaries such as Spencer Venugopal and Thanjavur Sankar Iyer — all these make Pattammal the musician beyond compare, of modern India.

Pattammal was no liberal as we comprehend the word today. Freedom, to her, meant being obedient to lofty traditional values and obedience was not a bad word! Independence, to her, meant non-interference in upholding dignity. With this faith and belief, she singularly brought about women’s liberation without ever mentioning that word.

Honours and awards came to her unsought. Even while being a busy performer, she continued to be a successful teacher and even trained a Chinese, Chong Chiu Sen, to be a Carnatic performer. But she remained a student and a typical Indian housewife, taking care of her husband, children, grandchildren and great grandchildren. Her extended family included several students of all ages.

The entire 90 years of her life and music teaches us just one mantra — Simplicity.

source: http://www.thehindu.com / The Hindu / Home> Entertainment> Music / by N Vijay Siva / March 15th, 2018

A knowledge hub for medicinal plants

Kariyat (Nilavembu) - Skullcapflavone
Kariyat (Nilavembu) – Skullcapflavone

Open source record of plants with “druggable” chemicals will help validate traditional systems

The use of Indian medicinal plants for drug discovery and therapeutics just received a boost. A database of such plants has been built by a Chennai-based team led by Areejit Samal of the Institute of Mathematical Sciences.

By documenting 1,742 Indian medicinal plants and 9,596 chemicals that plants use to thrive and ward off threats (phytochemicals), this database has the distinction of being the largest so far. This is a first step towards validating and developing traditional systems of medicine that use plant extracts.

For the repository, the scientists sourced information from several texts including those that documented tribal medicine. With supporting studies in the form of well-planned lab tests, this work has the potential to improve health care and enhance drug discovery.

Plants secrete various special chemicals to ward off predators, fight pathogens and survive in difficult situations. Some of these so-called phytochemicals have been used to prepare traditional medicines and also poisons. While there are extensive databases of phytochemicals of Chinese herbs, there has no similar work in India.

The new database, named IMPPAT (Indian Medicinal Plants, Phytochemistry And Therapeutics) brings together not just the Indian medicinal plants and their associated phytochemicals, but also the latter’s 2D and 3D chemical structures, the therapeutic use of the plants and the medicinal formulations.

Among the many challenges in building IMPPAT was in removing redundancy and standardising names and spellings that varied across the several books and documents they have referred to.

From previous work we know that natural products are made of highly complex molecules, which therefore are more likely to bind to very specific proteins unlike commercial (or synthesised) drug molecules.

“We show that phytochemicals in IMPPAT also have high stereochemical and shape complexity similar to natural product library of Clemons et al, and thus, IMPPAT phytochemicals are also expected to be specific protein binders,” says Areejit Samal. Drug molecules which are specific protein binders are likely to have fewer side-effects as they will bind specifically to their target protein.

Quest for druggability

The team analysed the features of the phytochemical structures using established “druggability” criteria.

This identified 960 potentially druggable phytochemicals of which only a small percentage showed similarities to existing FDA-approved drugs. “This offers immense potential for drug discovery,” says Dr Samal. Of the 960 phytochemicals, 14 have the highest druggability score, and one of these is Skullcapflavone I – This is produced by two plants, one of which is Andrographis paniculata, commonly known as Nilavembu or Siriyanangai. Another interesting topper is Kumatakenin, which is made by three plants including Artemisia capillaris. This plant is a close relative of Artemisia annuafrom which Nobel laureate Youyou Tu extracted the drug artemisinin which has saved the lives of many malaria patients.

“We hope to expand the links between phytochemicals of Indian medicinal plants and their target proteins, enabling application of systems biology… Our resource will help future efforts render Indian medicine evidence-based rather than experience-based,” says Dr Samal.

source: http://www.thehindu.com / The Hindu / Home> Sci-Tech> Environment / by Shubashree Desikan / Chennai – March 17th, 2018